In situ processing and distribution of intracerebrally injected OVA in the CNS
C Ling, M Sandor, Z Fabry - Journal of neuroimmunology, 2003 - Elsevier
Drainage and retention of brain-derived antigens are important factors in initiating and
regulating immune responses in the central nervous system (CNS). We investigated
distribution, immunological processing and retention of intracerebrally infused protein
antigen, ovalbumin (OVA), and the subsequent recruitment of CD8+ T cells into the CNS. We
found that protein antigens infused into the CNS can drain rapidly into the cervical lymph
node and initiate antigen-specific immune response in the periphery. A portion of the …
regulating immune responses in the central nervous system (CNS). We investigated
distribution, immunological processing and retention of intracerebrally infused protein
antigen, ovalbumin (OVA), and the subsequent recruitment of CD8+ T cells into the CNS. We
found that protein antigens infused into the CNS can drain rapidly into the cervical lymph
node and initiate antigen-specific immune response in the periphery. A portion of the …