[HTML][HTML] New insights in CD28‐independent allograft rejection
A Habicht, N Najafian, H Yagita, MH Sayegh… - American journal of …, 2007 - Elsevier
CD28 costimulatory blockade induces tolerance in most murine transplant models but fails
to do so in stringent transplant models, such as skin transplantation. The precise
immunological mechanisms of CD28‐independent rejection remain to be fully defined.
Using two novel mouse strains in which both CD28 and either CD4 or CD8 are knocked out
(CD4−/‐CD28−/‐or CD8−/‐CD28−/‐mice), we examined mechanisms of CD28‐independent
CD4+ or CD8+ T‐cell‐mediated allograft rejection. CD4−/‐CD28−/‐and CD8 …
to do so in stringent transplant models, such as skin transplantation. The precise
immunological mechanisms of CD28‐independent rejection remain to be fully defined.
Using two novel mouse strains in which both CD28 and either CD4 or CD8 are knocked out
(CD4−/‐CD28−/‐or CD8−/‐CD28−/‐mice), we examined mechanisms of CD28‐independent
CD4+ or CD8+ T‐cell‐mediated allograft rejection. CD4−/‐CD28−/‐and CD8 …