[HTML][HTML] Targeted phosphorylation of inositol 1, 4, 5-trisphosphate receptors selectively inhibits localized Ca2+ release and shapes oscillatory Ca2+ signals
DR Giovannucci, GE Groblewski, J Sneyd… - Journal of Biological …, 2000 - ASBMB
The current study provides biochemical and functional evidence that the targeting of protein
kinase A (PKA) to sites of localized Ca 2+ release confers rapid, specific phosphoregulation
of Ca 2+ signaling in pancreatic acinar cells. Regulatory control of Ca 2+ release by PKA-
dependent phosphorylation of inositol 1, 4, 5-trisphosphate (InsP 3) receptors was
investigated by monitoring Ca 2+ dynamics in pancreatic acinar cells evoked by the flash
photolysis of caged InsP 3 prior to and following PKA activation. Ca 2+ dynamics were …
kinase A (PKA) to sites of localized Ca 2+ release confers rapid, specific phosphoregulation
of Ca 2+ signaling in pancreatic acinar cells. Regulatory control of Ca 2+ release by PKA-
dependent phosphorylation of inositol 1, 4, 5-trisphosphate (InsP 3) receptors was
investigated by monitoring Ca 2+ dynamics in pancreatic acinar cells evoked by the flash
photolysis of caged InsP 3 prior to and following PKA activation. Ca 2+ dynamics were …