[HTML][HTML] The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival
KL Wu, S Khan, S Lakhe-Reddy, G Jarad… - Journal of Biological …, 2004 - ASBMB
Apoptosis results in cell shrinkage and intracellular acidification, processes opposed by the
ubiquitously expressed NHE1 Na+/H+ exchanger. In addition to mediating Na+/H+ transport,
NHE1 interacts with ezrin/radixin/moesin (ERM), which tethers NHE1 to cortical actin
cytoskeleton to regulate cell shape, adhesion, motility, and resistance to apoptosis. We
hypothesize that apoptotic stress activates NHE1-dependent Na+/H+ exchange, and NHE1-
ERM interaction is required for cell survival signaling. Apoptotic stimuli induced NHE1 …
ubiquitously expressed NHE1 Na+/H+ exchanger. In addition to mediating Na+/H+ transport,
NHE1 interacts with ezrin/radixin/moesin (ERM), which tethers NHE1 to cortical actin
cytoskeleton to regulate cell shape, adhesion, motility, and resistance to apoptosis. We
hypothesize that apoptotic stress activates NHE1-dependent Na+/H+ exchange, and NHE1-
ERM interaction is required for cell survival signaling. Apoptotic stimuli induced NHE1 …