[HTML][HTML] The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors

ME Meima, BA Webb, HE Witkowska… - Journal of biological …, 2009 - ASBMB
The kinase Akt mediates signals from growth factor receptors for increased cell proliferation,
survival, and migration, which contribute to the positive effects of Akt in cancer progression.
Substrates are generally inhibited when phosphorylated by Akt; however, we show
phosphorylation of the plasma membrane sodium-hydrogen exchanger NHE1 by Akt
increases exchanger activity (H+ efflux). Our data fulfill criteria for NHE1 being a bona fide
Akt substrate, including direct phosphorylation in vitro, using mass spectrometry and Akt …