[HTML][HTML] Activation of the ATP-sensitive K+ Channel by Long Chain Acyl-CoA: A ROLE IN MODULATION OF PANCREATIC β-CELL GLUCOSE SENSITIVITY (∗)
O Larsson, JT Deeney, R Bränström… - Journal of Biological …, 1996 - ASBMB
Long term exposure to elevated levels of long chain free fatty acids decreases glucose-
induced insulin secretion from pancreatic islets and clonal pancreatic β-cells. The
mechanism for this loss of glucose sensitivity is at present not known. In this study, we
evaluated the possibility that increases in long chain acyl-CoA esters (LC-CoA), the
metabolically active form of free fatty acids, might mediate the loss of glucose sensitivity. We
observed that cellular levels of LC-CoA increased more than 100% in response to overnight …
induced insulin secretion from pancreatic islets and clonal pancreatic β-cells. The
mechanism for this loss of glucose sensitivity is at present not known. In this study, we
evaluated the possibility that increases in long chain acyl-CoA esters (LC-CoA), the
metabolically active form of free fatty acids, might mediate the loss of glucose sensitivity. We
observed that cellular levels of LC-CoA increased more than 100% in response to overnight …