Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?
SJ Kish, Y Furukawa, LJ Chang, J Tong… - Nuclear medicine and …, 2005 - Elsevier
INTRODUCTION: The primary approach in assessing the status of brain serotonin neurons
in human conditions such as major depression and exposure to the illicit drug ecstasy has
been the use of neuroimaging procedures involving radiotracers that bind to the serotonin
transporter (SERT). However, there has been no consistency in the selection of a “SERT-
free” reference region for the estimation of free and nonspecific binding, as occipital cortex,
cerebellum and white matter have all been employed. OBJECTIVE AND METHODS: To …
in human conditions such as major depression and exposure to the illicit drug ecstasy has
been the use of neuroimaging procedures involving radiotracers that bind to the serotonin
transporter (SERT). However, there has been no consistency in the selection of a “SERT-
free” reference region for the estimation of free and nonspecific binding, as occipital cortex,
cerebellum and white matter have all been employed. OBJECTIVE AND METHODS: To …