Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA
T Maeda, K Nagata, Y Yoshida, K Kannari - Brain research, 2005 - Elsevier
T Maeda, K Nagata, Y Yoshida, K Kannari
Brain research, 2005•ElsevierThe aim of this study was to determine whether raphe-striatal serotonergic neurons of adult
rats with extensive nigro-striatal dopaminergic denervation are induced by injection of
exogenous l-DOPA to contain dopamine. Double-labeling immunofluorescence study was
conducted. In the lesioned striatum of rats that received l-DOPA, serotonergic
hyperinnervation was observed, and dopamine was detected in serotonergic varicose fibers.
These findings suggest that striatal serotonergic hyperinnervation can compensate for the …
rats with extensive nigro-striatal dopaminergic denervation are induced by injection of
exogenous l-DOPA to contain dopamine. Double-labeling immunofluorescence study was
conducted. In the lesioned striatum of rats that received l-DOPA, serotonergic
hyperinnervation was observed, and dopamine was detected in serotonergic varicose fibers.
These findings suggest that striatal serotonergic hyperinnervation can compensate for the …
The aim of this study was to determine whether raphe-striatal serotonergic neurons of adult rats with extensive nigro-striatal dopaminergic denervation are induced by injection of exogenous l-DOPA to contain dopamine. Double-labeling immunofluorescence study was conducted. In the lesioned striatum of rats that received l-DOPA, serotonergic hyperinnervation was observed, and dopamine was detected in serotonergic varicose fibers. These findings suggest that striatal serotonergic hyperinnervation can compensate for the lost function of dopaminergic neurons.
Elsevier