Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive
AV Buhler, J Choi, HK Proudfit, GF Gebhart - Pain, 2005 - Elsevier
Microinjection of neurotensin (NT) in the rostral ventromedial medulla (RVM) produces dose-
dependent antinociception. The NTR1 (Neurotensin Receptor Subtype 1) may mediate part
of this response, however definitive evidence is lacking, and the spinal mediators of NTR1-
induced antinociception are unknown. In the present study, we used immunohistochemical
techniques to show that the NTR1, but not the NTR2 is expressed by spinally projecting
serotonergic neurons of the RVM. We also show that microinjection of NT or the NTR1 …
dependent antinociception. The NTR1 (Neurotensin Receptor Subtype 1) may mediate part
of this response, however definitive evidence is lacking, and the spinal mediators of NTR1-
induced antinociception are unknown. In the present study, we used immunohistochemical
techniques to show that the NTR1, but not the NTR2 is expressed by spinally projecting
serotonergic neurons of the RVM. We also show that microinjection of NT or the NTR1 …