[HTML][HTML] Recognition of α2-macroglobulin by the low density lipoprotein receptor-related protein requires the cooperation of two ligand binding cluster regions
I Mikhailenko, FD Battey, M Migliorini, JF Ruiz… - Journal of biological …, 2001 - ASBMB
The low density lipoprotein receptor-related protein (LRP) is a scavenger receptor that binds
several ligands including the activated form of the pan-proteinase inhibitor α 2-
macroglobulin (α 2 M*) and amyloid precursor protein, two ligands genetically linked to
Alzheimer's disease. To delineate the contribution of LRP to this disease, it will be necessary
to identify the sites on this receptor which are responsible for recognizing these and other
ligands to assist in the development of specific inhibitors. Structurally, LRP contains four …
several ligands including the activated form of the pan-proteinase inhibitor α 2-
macroglobulin (α 2 M*) and amyloid precursor protein, two ligands genetically linked to
Alzheimer's disease. To delineate the contribution of LRP to this disease, it will be necessary
to identify the sites on this receptor which are responsible for recognizing these and other
ligands to assist in the development of specific inhibitors. Structurally, LRP contains four …