Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages
During normal tissue homeostasis apoptotic cells (AC) are rapidly recognised and engulfed
by neighbouring cells or macrophages (Mφ), thus preventing an inflammatory response.
Conversely, in chronically inflamed tissues, including the atherosclerotic artery and
rheumatoid joint, removal of AC is defective despite the co-localisation of seemingly
adequate numbers of Mφ. Mechanisms preventing removal of AC in vivo remain obscure,
but might include oxidised low-density lipoprotein (ox-LDL), which is abundant in chronic …
by neighbouring cells or macrophages (Mφ), thus preventing an inflammatory response.
Conversely, in chronically inflamed tissues, including the atherosclerotic artery and
rheumatoid joint, removal of AC is defective despite the co-localisation of seemingly
adequate numbers of Mφ. Mechanisms preventing removal of AC in vivo remain obscure,
but might include oxidised low-density lipoprotein (ox-LDL), which is abundant in chronic …