[PDF][PDF] Phagocytic signaling: you can touch, but you can't eat
JM Kinchen, KS Ravichandran - Current biology, 2008 - cell.com
JM Kinchen, KS Ravichandran
Current biology, 2008•cell.comPhagocytic Signaling: You Can Touch, but You Can’t Eat Page 1 estimate becomes more
reliable. But it is optimal to not use the second source — or at least to weight it differently — if
the system knows that there is a chance that the modality signals may be biased relative to
one another, which might occur during body growth or tool use. In this case, there is a
potential cost in using the second source of information because the combined estimate would
be biased [16,18]. Adults seem to be able to use the available sensory information differently …
reliable. But it is optimal to not use the second source — or at least to weight it differently — if
the system knows that there is a chance that the modality signals may be biased relative to
one another, which might occur during body growth or tool use. In this case, there is a
potential cost in using the second source of information because the combined estimate would
be biased [16,18]. Adults seem to be able to use the available sensory information differently …
Summary
The ability of phagocytes to discriminate between viable/healthy and apoptotic/foreign/abnormal cells is of fundamental importance; a recent study provides new molecular insights into the function of CD47–SIRPα signaling in this discrimination.
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