[HTML][HTML] Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)
D Chiluiza, S Krishna, VA Schumacher… - Journal of Biological …, 2013 - ASBMB
Gain-of-function mutations in the canonical transient receptor potential 6 (TRPC6) gene are
a cause of autosomal dominant focal segmental glomerulosclerosis (FSGS). The
mechanisms whereby abnormal TRPC6 activity results in proteinuria remain unknown. The
ERK1/2 MAPKs are activated in glomeruli and podocytes in several proteinuric disease
models. We therefore examined whether FSGS-associated mutations in TRPC6 result in
activation of these kinases. In 293T cells and cultured podocytes, overexpression of gain-of …
a cause of autosomal dominant focal segmental glomerulosclerosis (FSGS). The
mechanisms whereby abnormal TRPC6 activity results in proteinuria remain unknown. The
ERK1/2 MAPKs are activated in glomeruli and podocytes in several proteinuric disease
models. We therefore examined whether FSGS-associated mutations in TRPC6 result in
activation of these kinases. In 293T cells and cultured podocytes, overexpression of gain-of …