Hepatic competence, specification, and liver bud expansion during development depend on
precise temporal modulation of the Wnt/β-catenin signaling. Also, loss-and gain-of-function
studies have revealed pleiotropic roles of β-catenin in proliferation and hepatocyte and
biliary epithelial cell differentiation, but precise mechanisms remain unknown. Here we
utilize livers from different stages of murine development to determine β-catenin signaling
and downstream targets. Although during early liver development full-length β-catenin is the …