[HTML][HTML] Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK)

KT Chan, DA Bennin, A Huttenlocher - Journal of Biological Chemistry, 2010 - ASBMB
The coordinated and dynamic regulation of adhesions is required for cell migration. We
demonstrated previously that limited proteolysis of talin1 by the calcium-dependent protease
calpain 2 plays a critical role in adhesion disassembly in fibroblasts (Franco, SJ, Rodgers,
MA, Perrin, BJ, Han, J., Bennin, DA, Critchley, DR, and Huttenlocher, A.(2004) Nat. Cell Biol.
6, 977–983). However, little is known about the contribution of other calpain substrates to the
regulation of adhesion dynamics. We now provide evidence that calpain 2-mediated …