[HTML][HTML] Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation

S Flajollet, B Lefebvre, C Rachez, P Lefebvre - Journal of biological …, 2006 - ASBMB
Retinoic acid receptors (RARs) are the molecular relays of retinoid action on transcription,
cellular differentiation and apoptosis. Transcriptional activation of retinoid-regulated
promoters requires the dismissal of corepressors and the recruitment of coactivators to
promoter-bound RAR. RARs recruit in vitro a plethora of coactivators whose actual
contribution to retinoid-induced transcription is poorly characterized in vivo. Embryonal
carcinoma P19 cells, which are highly sensitive to retinoids, were depleted from archetypical …