[HTML][HTML] Unexpected outcome (positive or negative) including adverse drug reactions: Metformin-induced cholangiohepatitis
RSRS Biyyani, S Battula, CA Erhardt… - BMJ Case Reports, 2009 - ncbi.nlm.nih.gov
RSRS Biyyani, S Battula, CA Erhardt, K Korkor
BMJ Case Reports, 2009•ncbi.nlm.nih.govDrug-induced cholangiohepatitis accounts for 20–50% of non-viral chronic hepatitis cases.
Metformin is the most commonly prescribed oral anti-diabetic drug from the biguanide class
used in treatment of overweight and obese type 2 diabetes mellitus patients. Metformin-
induced cholangiohepatitis with marked elevations in serum liver transaminases and
intrahepatic cholestasis has been infrequently reported. Here, we report a case of acute
cholangiohepatitis after initiation of metformin treatment. BACKGROUND This case …
Metformin is the most commonly prescribed oral anti-diabetic drug from the biguanide class
used in treatment of overweight and obese type 2 diabetes mellitus patients. Metformin-
induced cholangiohepatitis with marked elevations in serum liver transaminases and
intrahepatic cholestasis has been infrequently reported. Here, we report a case of acute
cholangiohepatitis after initiation of metformin treatment. BACKGROUND This case …
Abstract
Drug-induced cholangiohepatitis accounts for 20–50% of non-viral chronic hepatitis cases. Metformin is the most commonly prescribed oral anti-diabetic drug from the biguanide class used in treatment of overweight and obese type 2 diabetes mellitus patients. Metformin-induced cholangiohepatitis with marked elevations in serum liver transaminases and intrahepatic cholestasis has been infrequently reported. Here, we report a case of acute cholangiohepatitis after initiation of metformin treatment.
BACKGROUND
This case highlights the presentation of drug-induced cholangiohepatitis due to a commonly prescribed medication. Drug-induced cholangiohepatitis should be considered in the differential diagnosis of patients presenting with right upper quadrant abdominal pain and liver enzyme abnormalities.
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