[HTML][HTML] Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1
M Ananthanarayanan, SD Li… - Journal of Biological …, 2004 - ASBMB
In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor
(FXR), incorporates histone methyltransferase activity within the gene locus for bile salt
export pump (BSEP), a well established FXR target gene that functions as an ATP-
dependent canalicular bile acid transporter. This methyltransferase activity is directed
specifically to arginine 17 of histone H3. We demonstrate that FXR is directly associated with
co-activator-associated arginine methyltransferase 1 (CARM1) activity. Furthermore, we …
(FXR), incorporates histone methyltransferase activity within the gene locus for bile salt
export pump (BSEP), a well established FXR target gene that functions as an ATP-
dependent canalicular bile acid transporter. This methyltransferase activity is directed
specifically to arginine 17 of histone H3. We demonstrate that FXR is directly associated with
co-activator-associated arginine methyltransferase 1 (CARM1) activity. Furthermore, we …