[HTML][HTML] Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid β peptide generation
MK Lakshmana, IS Yoon, E Chen, E Bianchi… - Journal of biological …, 2009 - ASBMB
Accumulation of the amyloid β (Aβ) peptide derived from the proteolytic processing of
amyloid precursor protein (APP) is the defining pathological hallmark of Alzheimer disease.
We previously demonstrated that the C-terminal 37 amino acids of lipoprotein receptor-
related protein (LRP) robustly promoted Aβ generation independent of FE65 and specifically
interacted with Ran-binding protein 9 (RanBP9). In this study we found that RanBP9 strongly
increased BACE1 cleavage of APP and Aβ generation. This pro-amyloidogenic activity of …
amyloid precursor protein (APP) is the defining pathological hallmark of Alzheimer disease.
We previously demonstrated that the C-terminal 37 amino acids of lipoprotein receptor-
related protein (LRP) robustly promoted Aβ generation independent of FE65 and specifically
interacted with Ran-binding protein 9 (RanBP9). In this study we found that RanBP9 strongly
increased BACE1 cleavage of APP and Aβ generation. This pro-amyloidogenic activity of …