39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
J Herz, JL Goldstein, DK Strickland, YK Ho… - Journal of Biological …, 1991 - ASBMB
A 39-kDa protein of unknown function has previously been reported to copurify with the low
density lipoprotein receptor-related protein (LRP)/alpha 2-macroglobulin receptor. In this
study we demonstrate that a recombinant 39-kDa fusion protein can reversibly bind to the
515-kDa subunit of the LRP/alpha 2-macroglobulin receptor. This interaction inhibits the
binding and uptake of the receptor's two known ligands: 1) beta-migrating very low density
lipoproteins activated by enrichment with apoprotein E and 2) alpha 2-macroglobulin …
density lipoprotein receptor-related protein (LRP)/alpha 2-macroglobulin receptor. In this
study we demonstrate that a recombinant 39-kDa fusion protein can reversibly bind to the
515-kDa subunit of the LRP/alpha 2-macroglobulin receptor. This interaction inhibits the
binding and uptake of the receptor's two known ligands: 1) beta-migrating very low density
lipoproteins activated by enrichment with apoprotein E and 2) alpha 2-macroglobulin …