TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) signals through Toll-like receptor 2 (TLR2) to regulate
antigen presenting cells (APCs). Mtb lipoproteins, including LpqH, LprA, LprG and PhoS1,
are TLR2 agonists, but their co-receptor requirements are unknown. We studied Mtb
lipoprotein-induced responses in TLR2−/−, TLR1−/−, TLR6−/−, CD14−/− and CD36−/−
macrophages. Responses to LprA, LprG, LpqH and PhoS1 were completely dependent on
TLR2. LprG, LpqH, and PhoS1 were dependent on TLR1, but LprA did not require TLR1 …
antigen presenting cells (APCs). Mtb lipoproteins, including LpqH, LprA, LprG and PhoS1,
are TLR2 agonists, but their co-receptor requirements are unknown. We studied Mtb
lipoprotein-induced responses in TLR2−/−, TLR1−/−, TLR6−/−, CD14−/− and CD36−/−
macrophages. Responses to LprA, LprG, LpqH and PhoS1 were completely dependent on
TLR2. LprG, LpqH, and PhoS1 were dependent on TLR1, but LprA did not require TLR1 …