B cells are recognized as effector cells in allograft rejection that are dependent upon T cell
help to produce alloantibodies causing graft injury. It is not known if B cells can also help T
cells differentiate into memory cells in the alloimmune response. We found that in B‐cell‐
deficient hosts, differentiation of alloreactive T cells into effectors was intact whereas their
development into memory T cells was impaired. To test if B cell help for T cells was required
for their continued differentiation into memory T cells, activated T cells were sorted from …