[HTML][HTML] Tumor necrosis factor receptor‐1 and‐2 double deficiency reduces graft arterial disease in murine cardiac allografts
J Suzuki, SE Cole, S Batirel, H Kosuge… - American Journal of …, 2003 - Elsevier
Graft arterial disease (GAD) remains the leading cause of long‐term solid organ allograft
failure. Tumor necrosis factor (TNF) promotes multiple aspects of allograft rejection via
binding to type 1 (p55) and type 2 (p75) receptors. We used TNF type 1 receptor deficient
(TNFR1KO), type 2 receptor deficient (TNFR2KO) and receptor double‐deficient
(TNFRDKO) mice to assess the relative roles of TNFR in acute rejection and GAD.
Heterotopic cardiac transplantation was performed between C57BL/6 (B/6) and Balb/c (B/c) …
failure. Tumor necrosis factor (TNF) promotes multiple aspects of allograft rejection via
binding to type 1 (p55) and type 2 (p75) receptors. We used TNF type 1 receptor deficient
(TNFR1KO), type 2 receptor deficient (TNFR2KO) and receptor double‐deficient
(TNFRDKO) mice to assess the relative roles of TNFR in acute rejection and GAD.
Heterotopic cardiac transplantation was performed between C57BL/6 (B/6) and Balb/c (B/c) …