Owing to the discovery that rare leukemia-initiating cells (or leukemia stem cells, LSC) give
origin to and propagate a hierarchical cellular organization of variably differentiated
leukemic blasts, the analysis of precisely defined stem and progenitor cells have
increasingly gained importance. Emergence of multi-parameter high-speed fluorescence-
activated cell sorting (FACS) for the subfractionation of hematopoietic progenitor cells has
allowed research on the biology of the cell-of-origin for LSCs and of LSCs as potential (or …