There are two isozymes of angiotensin-converting enzyme (ACE), one produced by somatic
tissues and a smaller protein synthesized by developing spermatozoa (testis ACE). To
investigate the molecular control of testis ACE, we generated mice transgenic for a construct
containing a putative testis-specific ACE promoter linked to the Escherichia coli reporter
gene encoding beta-galactosidase. The transgenic mice express beta-galactosidase protein
and RNA only within the testis. Histochemical analysis of the transgenic mice shows co …