Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus
D Okwan-Duodu, V Datta, XZ Shen… - Journal of biological …, 2010 - ASBMB
Gene targeting in ES cells was used to substitute control of angiotensin converting enzyme
(ACE) expression from the endogenous promoter to the mouse c-fms promoter. The result is
an animal model called ACE 10/10 in which ACE is overexpressed by monocytes,
macrophages, and other myelomonocytic lineage cells. To study the immune response of
these mice to bacterial infection, we challenged them with Listeria monocytogenes or
methicillin-resistant Staphylococcus aureus (MRSA). ACE 10/10 mice have a significantly …
(ACE) expression from the endogenous promoter to the mouse c-fms promoter. The result is
an animal model called ACE 10/10 in which ACE is overexpressed by monocytes,
macrophages, and other myelomonocytic lineage cells. To study the immune response of
these mice to bacterial infection, we challenged them with Listeria monocytogenes or
methicillin-resistant Staphylococcus aureus (MRSA). ACE 10/10 mice have a significantly …
