Feasibility of retinoids for the treatment of emphysema study
MD Roth, JE Connett, JM D'Armiento, RF Foronjy… - Chest, 2006 - Elsevier
Background Retinoids promote alveolar septation in the developing lung and stimulate
alveolar repair in some animal models of emphysema. Methods One hundred forty-eight
subjects with moderate-to-severe COPD and a primary component of emphysema, defined
by diffusing capacity of the lung for carbon monoxide (D lco)[37.1±12.0% of predicted] and
CT density mask (38.5±12.8% of voxels<− 910 Hounsfield units)[mean±SD] were enrolled
into a randomized, double-blind, feasibility study at five university hospitals. Participants …
alveolar repair in some animal models of emphysema. Methods One hundred forty-eight
subjects with moderate-to-severe COPD and a primary component of emphysema, defined
by diffusing capacity of the lung for carbon monoxide (D lco)[37.1±12.0% of predicted] and
CT density mask (38.5±12.8% of voxels<− 910 Hounsfield units)[mean±SD] were enrolled
into a randomized, double-blind, feasibility study at five university hospitals. Participants …