[HTML][HTML] Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
MG Harisinghani, J Barentsz, PF Hahn… - … England Journal of …, 2003 - Mass Medical Soc
MG Harisinghani, J Barentsz, PF Hahn, WM Deserno, S Tabatabaei, CH van de Kaa…
New England Journal of Medicine, 2003•Mass Medical SocBackground Accurate detection of lymph-node metastases in prostate cancer is an essential
component of the approach to treatment. We investigated whether highly lymphotropic
superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial–
lymphatic fluid transport, could be used in conjunction with high-resolution magnetic
resonance imaging (MRI) to reveal small nodal metastases. Methods Eighty patients with
presurgical clinical stage T1, T2, or T3 prostate cancer who underwent surgical lymph-node …
component of the approach to treatment. We investigated whether highly lymphotropic
superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial–
lymphatic fluid transport, could be used in conjunction with high-resolution magnetic
resonance imaging (MRI) to reveal small nodal metastases. Methods Eighty patients with
presurgical clinical stage T1, T2, or T3 prostate cancer who underwent surgical lymph-node …
Background
Accurate detection of lymph-node metastases in prostate cancer is an essential component of the approach to treatment. We investigated whether highly lymphotropic superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial–lymphatic fluid transport, could be used in conjunction with high-resolution magnetic resonance imaging (MRI) to reveal small nodal metastases.
Methods
Eighty patients with presurgical clinical stage T1, T2, or T3 prostate cancer who underwent surgical lymph-node resection or biopsy were enrolled. All patients were examined by MRI before and 24 hours after the intravenous administration of lymphotropic superparamagnetic nanoparticles (2.6 mg of iron per kilogram of body weight). The imaging results were correlated with histopathological findings.
Results
Of the 334 lymph nodes that underwent resection or biopsy, 63 (18.9 percent) from 33 patients (41 percent) had histopathologically detected metastases. Of these 63 nodes, 45 (71.4 percent) did not fulfill the usual imaging criteria for malignancy. MRI with lymphotropic superparamagnetic nanoparticles correctly identified all patients with nodal metastases, and a node-by-node analysis had a significantly higher sensitivity than conventional MRI (90.5 percent vs. 35.4 percent, P<0.001) or nomograms.
Conclusions
High-resolution MRI with magnetic nanoparticles allows the detection of small and otherwise undetectable lymph-node metastases in patients with prostate cancer.
The New England Journal Of Medicine