Aggrus, also called T1α and podoplanin, is a novel platelet aggregation-inducing factor that
is expressed in various carcinoma cells. Aggrus/T1α/podoplanin is known to be expressed
in lung type I alveolar cells or lymphatic endothelial cells. However, its physiological role has
not been clarified. To assess the attribution of glycosylation to Aggrus platelet aggregation
activity, recombinant molecules were stably expressed in a series of Chinese hamster ovary
(CHO) cell mutants, N-glycan-deficient Lec1, CMP-sialic acid transporter-deficient Lec2, and …