[HTML][HTML] Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
GG Van den Eynden, I Van der Auwera… - British journal of …, 2006 - nature.com
GG Van den Eynden, I Van der Auwera, SJ Van Laere, V Huygelen, CG Colpaert…
British journal of cancer, 2006•nature.comWe studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast
cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of
104 (25.0%) uninvolved LNs (P< 0.001). Furthermore, median intra-and perinodal lymphatic
endothelial cell proliferation fractions were higher in metastatically involved LNs (P< 0.001).
This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in
general and breast cancer in particular.
cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of
104 (25.0%) uninvolved LNs (P< 0.001). Furthermore, median intra-and perinodal lymphatic
endothelial cell proliferation fractions were higher in metastatically involved LNs (P< 0.001).
This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in
general and breast cancer in particular.
Abstract
We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P< 0.001). Furthermore, median intra-and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P< 0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular.
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