Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen
PN Chander, O Gealekman, SV Brodsky… - Journal of the …, 2004 - journals.lww.com
Zucker diabetic fat (ZDF) rats with the metabolic syndrome and hyperlipidemia develop focal
and segmental sclerosis. The role of oxidative and nitrosative stress in the nephropathy in
ZDF was studied. Renal histology, function, and immunohistologic and biochemical
parameters of oxidative and nitrosative stress were evaluated at 8 and 22 wk of age in ZDF
and Zucker lean (ZL) rats and after chronic treatment with ebselen, an antioxidant and
peroxinitrite scavenger. At 8 wk, ZDF rats showed hyperglycemia, no proteinuria or …
and segmental sclerosis. The role of oxidative and nitrosative stress in the nephropathy in
ZDF was studied. Renal histology, function, and immunohistologic and biochemical
parameters of oxidative and nitrosative stress were evaluated at 8 and 22 wk of age in ZDF
and Zucker lean (ZL) rats and after chronic treatment with ebselen, an antioxidant and
peroxinitrite scavenger. At 8 wk, ZDF rats showed hyperglycemia, no proteinuria or …