Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c
Y Achouri, BD Hegarty, D Allanic, D Becard, I Hainault… - Biochimie, 2005 - Elsevier
In a screen for sterol regulatory element-binding protein (SREBP)-1c target genes in the
liver, we identified long chain fatty acyl-CoA synthetase 5 (ACS-5). Hepatic ACS-5 mRNA is
poorly expressed during fasting and diabetes and strongly induced by carbohydrate
refeeding and insulin treatment. In cultured hepatocytes, insulin and a high glucose
concentration induce ACS-5 mRNA. Adenoviral overexpression of a nuclear form of SREBP-
1c in liver of diabetic mice or in cultured hepatocytes mimics the effect of insulin to induce …
liver, we identified long chain fatty acyl-CoA synthetase 5 (ACS-5). Hepatic ACS-5 mRNA is
poorly expressed during fasting and diabetes and strongly induced by carbohydrate
refeeding and insulin treatment. In cultured hepatocytes, insulin and a high glucose
concentration induce ACS-5 mRNA. Adenoviral overexpression of a nuclear form of SREBP-
1c in liver of diabetic mice or in cultured hepatocytes mimics the effect of insulin to induce …