Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-γ
M Arici, R Chana, A Lewington, J Brown… - Journal of the …, 2003 - journals.lww.com
In nephrotic syndrome, large quantities of albumin enter the kidney tubule. This albumin
carries with it a heavy load of fatty acids to which the proximal tubule cells are exposed at
high concentration. It is postulated that exposure to fatty acids in this way is injurious to
proximal tubule cells. This study has examined the ability of fatty acids to interact with
peroxisome proliferator–activated receptors (PPAR) in primary cultures of human proximal
tubule cells. Luciferase reporter assays in transiently transfected human proximal tubule …
carries with it a heavy load of fatty acids to which the proximal tubule cells are exposed at
high concentration. It is postulated that exposure to fatty acids in this way is injurious to
proximal tubule cells. This study has examined the ability of fatty acids to interact with
peroxisome proliferator–activated receptors (PPAR) in primary cultures of human proximal
tubule cells. Luciferase reporter assays in transiently transfected human proximal tubule …