Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4
MB Soyka, P Wawrzyniak, T Eiwegger… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Chronic rhinosinusitis (CRS) is a common disease with still unclear
pathophysiologic mechanisms. Epithelial tight junctions (TJs) have been shown to be
involved in different chronic disorders, including bronchial asthma, inflammatory bowel
diseases, and skin disorders. The regulation of epithelial barrier function and TJ expression
has not been extensively studied in patients with CRS and in the paranasal sinus epithelium
thus far. OBJECTIVE: We sought to elucidate the TJ expression pattern in the epithelium of …
pathophysiologic mechanisms. Epithelial tight junctions (TJs) have been shown to be
involved in different chronic disorders, including bronchial asthma, inflammatory bowel
diseases, and skin disorders. The regulation of epithelial barrier function and TJ expression
has not been extensively studied in patients with CRS and in the paranasal sinus epithelium
thus far. OBJECTIVE: We sought to elucidate the TJ expression pattern in the epithelium of …