Accelerated atherosclerosis in ApoE deficient lupus mouse models
Z Ma, A Choudhury, SA Kang, M Monestier… - Clinical …, 2008 - Elsevier
The accelerated development of atherosclerosis with increased risk of cardiovascular
disease in systemic lupus erythematosus (SLE) patients is not well understood. An
appropriate mouse model would greatly help to understand the mechanisms of this
association. We have therefore combined the ApoE−/− model of atherosclerosis with three
different murine models of SLE. We found that induction of cGVH in B6. ApoE−/− mice,
breeding a Fas null gene onto the B6. ApoE−/− mice, and breeding the ApoE−/− defect onto …
disease in systemic lupus erythematosus (SLE) patients is not well understood. An
appropriate mouse model would greatly help to understand the mechanisms of this
association. We have therefore combined the ApoE−/− model of atherosclerosis with three
different murine models of SLE. We found that induction of cGVH in B6. ApoE−/− mice,
breeding a Fas null gene onto the B6. ApoE−/− mice, and breeding the ApoE−/− defect onto …