Chemokines as regulators of T cell differentiation

SA Luther, JG Cyster - Nature immunology, 2001 - nature.com
SA Luther, JG Cyster
Nature immunology, 2001nature.com
Chemokines play well established roles as attractants of naïve and effector T cells. New
studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking
G i protein–coupled receptor signaling by pertussis toxin as well as deficiencies in Gα i2,
chemokine receptor 2 (CCR2), CCR5, chemokine ligand 2 (CCL2, also known as monocyte
chemoattractant protein 1, or MCP-1), CCL3 (macrophage inflammatory protein 1α, or MIP-
1α) and CCL5 (RANTES) have all been found to have effects on the magnitude and cytokine …
Abstract
Chemokines play well established roles as attractants of naïve and effector T cells. New studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking G i protein–coupled receptor signaling by pertussis toxin as well as deficiencies in Gα i2, chemokine receptor 2 (CCR2), CCR5, chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein 1, or MCP-1), CCL3 (macrophage inflammatory protein 1α, or MIP-1α) and CCL5 (RANTES) have all been found to have effects on the magnitude and cytokine polarity of the T cell response. Here we focus on findings in the CCL2-CCR2 and CCL3-CCR5 ligand-receptor systems. The roles of these molecules in regulating T cell fate include possible indirect effects on antigen-presenting cells and direct effects on differentiating T cells. Models to account for the action of chemokines and G protein–coupled receptor signals in regulating T cell differentiation are discussed.
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