N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.
The imino sugar deoxynojirimycin and its alkylated derivatives are inhibitors of the N-linked
oligosaccharide processing enzymes alpha-glucosidase I and II. These compounds are
glucose analogues and have the potential to inhibit both glucosidases and
glucosyltransferases. However, to date there has been no report of deoxynojirimycin or
similar analogues inhibiting a mammalian glucosyltransferase. We have investigated the
effects of deoxynojirimycin and its alkylated derivatives on the biosynthesis of glycolipids in …
oligosaccharide processing enzymes alpha-glucosidase I and II. These compounds are
glucose analogues and have the potential to inhibit both glucosidases and
glucosyltransferases. However, to date there has been no report of deoxynojirimycin or
similar analogues inhibiting a mammalian glucosyltransferase. We have investigated the
effects of deoxynojirimycin and its alkylated derivatives on the biosynthesis of glycolipids in …