Macrophages are phagocytic cells that produce and release reactive oxygen species (ROS)
in response to phagocytosis or stimulation with various agents. The enzyme responsible for
the production of superoxide and hydrogen peroxide is a multi-component NADPH oxidase
that requires assembly at the plasma membrane to function as an oxidase. In addition to
participating in bacterial killing, ROS, which have recently been shown to be produced
enzymatically by non-phagocytic cells, have been implicated in inflammation and tissue …