Human brain tumor xenografts in nude mice as a chemotherapy model
DP Houchens, AA Ovejera, SM Riblet… - European Journal of …, 1983 - Elsevier
Two human brain tumors which were previously established in nude mice were used to
determine antitumor efficacy of various therapeutic agents. These tumors were a
medulloblastoma (TE-671) and a glioma (U-251) with mass doubling times of 3.5 and 5.5
days respectively as subcutaneous implants in nude mice. Intracranial (ic) tumor challenge
was accomplished by inoculating tissue culture-grown cells of either tumor into the right
cerebral hemisphere to a depth of 3 mm. Median survival time (MST) in untreated mice with …
determine antitumor efficacy of various therapeutic agents. These tumors were a
medulloblastoma (TE-671) and a glioma (U-251) with mass doubling times of 3.5 and 5.5
days respectively as subcutaneous implants in nude mice. Intracranial (ic) tumor challenge
was accomplished by inoculating tissue culture-grown cells of either tumor into the right
cerebral hemisphere to a depth of 3 mm. Median survival time (MST) in untreated mice with …