NKCC1 and hypertension: a novel therapeutic target involved in the regulation of vascular tone and renal function
SN Orlov, J Tremblay, P Hamet - Current opinion in nephrology …, 2010 - journals.lww.com
SN Orlov, J Tremblay, P Hamet
Current opinion in nephrology and hypertension, 2010•journals.lww.comNKCC1 modulates BP through vascular and renal effects. In addition to BP regulation, the
decreased baseline activity of this carrier or its suppression by chronic treatment with HCDs
may lead to inhibition of myogenic tone and progression of end-stage renal disease. NKCC1
activation in ischemia-induced acidosis may contribute to stroke via glutamate release
caused by astrocyte swelling.
decreased baseline activity of this carrier or its suppression by chronic treatment with HCDs
may lead to inhibition of myogenic tone and progression of end-stage renal disease. NKCC1
activation in ischemia-induced acidosis may contribute to stroke via glutamate release
caused by astrocyte swelling.
Summary
NKCC1 modulates BP through vascular and renal effects. In addition to BP regulation, the decreased baseline activity of this carrier or its suppression by chronic treatment with HCDs may lead to inhibition of myogenic tone and progression of end-stage renal disease. NKCC1 activation in ischemia-induced acidosis may contribute to stroke via glutamate release caused by astrocyte swelling.
Lippincott Williams & Wilkins