[HTML][HTML] Functional brown adipose tissue in healthy adults

KA Virtanen, ME Lidell, J Orava… - … England Journal of …, 2009 - Mass Medical Soc
KA Virtanen, ME Lidell, J Orava, M Heglind, R Westergren, T Niemi, M Taittonen, J Laine
New England Journal of Medicine, 2009Mass Medical Soc
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was
increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy
subjects. We obtained biopsy specimens of this tissue from the first three consecutive
subjects and documented messenger RNA (mRNA) and protein levels of the brown-
adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment,
which showed numerous multilocular, intracellular lipid droplets, and with the results of …
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
The New England Journal Of Medicine