Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin
RQ Sun, YJ Tu, JY Yan, WD Willis - Pain, 2006 - Elsevier
We investigated the involvement of the protein kinase B/Akt (PKB/Akt) signaling pathway in
the mechanical hypersensitivity induced in rats by capsaicin. Intradermal injection of
capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the
dorsal horn, starting by 5min after capsaicin injection and lasting at least 1h. The activated
PKB/Akt in the spinal cord is in neurons, since phospho-PKB/Akt (p-PKB/Akt) colocalizes
with the neuronal marker, neuronal-specific nuclear protein (NeuN). The mechanical …
the mechanical hypersensitivity induced in rats by capsaicin. Intradermal injection of
capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the
dorsal horn, starting by 5min after capsaicin injection and lasting at least 1h. The activated
PKB/Akt in the spinal cord is in neurons, since phospho-PKB/Akt (p-PKB/Akt) colocalizes
with the neuronal marker, neuronal-specific nuclear protein (NeuN). The mechanical …