[HTML][HTML] Glutamatergic regulation of the p70S6 kinase in primary mouse neurons
Brief glutamatergic stimulation of neurons from fetal mice, cultured in vitro for 6 days,
activates the mTOR-S6 kinase, ERK1/2 and Akt pathways, to an extent approaching that
elicited by brain-derived neurotrophic factor. In contrast, sustained glutamatergic stimulation
inhibits ERK, Akt, and S6K. Glutamatergic activation of S6K is calcium/calmodulin-
dependent and is prevented by inhibitors of calcium/calmodulin-dependent protein kinase 2,
phosphatidylinositol 3-OH-kinase and by rapamycin. 2-Amino-5-phosphonovaleric acid, an …
activates the mTOR-S6 kinase, ERK1/2 and Akt pathways, to an extent approaching that
elicited by brain-derived neurotrophic factor. In contrast, sustained glutamatergic stimulation
inhibits ERK, Akt, and S6K. Glutamatergic activation of S6K is calcium/calmodulin-
dependent and is prevented by inhibitors of calcium/calmodulin-dependent protein kinase 2,
phosphatidylinositol 3-OH-kinase and by rapamycin. 2-Amino-5-phosphonovaleric acid, an …