[HTML][HTML] Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130
MP Cooper, M Uldry, S Kajimura, Z Arany… - Journal of biological …, 2008 - ASBMB
The PGC-1 coactivators are important regulators of oxidative metabolism. We previously
demonstrated that LRP130 is a binding partner of PGC-1α, required for hepatic
gluconeogenesis. LRP130 is the gene mutated in Leigh syndrome French Canadian variant,
a rare neurodegenerative disease. The importance of LRP130 in other, non-hepatocyte
biology remains obscure. To better understand PGC-1 coactivator function in brown fat
development, we explored the metabolic role of LRP130 in brown adipocyte differentiation …
demonstrated that LRP130 is a binding partner of PGC-1α, required for hepatic
gluconeogenesis. LRP130 is the gene mutated in Leigh syndrome French Canadian variant,
a rare neurodegenerative disease. The importance of LRP130 in other, non-hepatocyte
biology remains obscure. To better understand PGC-1 coactivator function in brown fat
development, we explored the metabolic role of LRP130 in brown adipocyte differentiation …