Activation of human vascular cells decreases their expression of transforming growth factor-beta
AH Lebastchi, L Qin, SF Khan, J Zhou, A Geirsson… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: Despite pro-fibrotic effects, transforming growth factor (TGF)-β prevents
arteriosclerosis by suppressing effector leukocytes and promoting smooth muscle
differentiation. However, previous observations of increased TGF-β expression in
arteriosclerotic plaques are not consistent with that of an effective protective factor. We
investigated the expression, regulation, and responses of TGF-β in human arterial tissues
and cells. METHODS AND RESULTS: The expression of TGF-β by intrinsic vascular cells …
arteriosclerosis by suppressing effector leukocytes and promoting smooth muscle
differentiation. However, previous observations of increased TGF-β expression in
arteriosclerotic plaques are not consistent with that of an effective protective factor. We
investigated the expression, regulation, and responses of TGF-β in human arterial tissues
and cells. METHODS AND RESULTS: The expression of TGF-β by intrinsic vascular cells …