Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa
K Guerin, CY Gregory-Evans, MD Hodges… - Experimental eye …, 2008 - Elsevier
We studied the potential of systemically administered aminoglycosides as a therapy for
retinal degeneration resulting from premature termination codon (PTC) mutations.
Aminoglycosides were systemically delivered to two rodent models of retinal degeneration:
a transgenic rat model of dominant disease caused by a PTC in rhodopsin (S334ter); and a
mouse model of recessive disease (rd12) caused by a PTC in the retinoid isomerase Rpe65.
Initial luciferase reporter assays were undertaken to measure the efficiency of gentamicin …
retinal degeneration resulting from premature termination codon (PTC) mutations.
Aminoglycosides were systemically delivered to two rodent models of retinal degeneration:
a transgenic rat model of dominant disease caused by a PTC in rhodopsin (S334ter); and a
mouse model of recessive disease (rd12) caused by a PTC in the retinoid isomerase Rpe65.
Initial luciferase reporter assays were undertaken to measure the efficiency of gentamicin …