Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2

K Yokoyama, H Suzuki, K Yasumoto, Y Tomita… - … et Biophysica Acta (BBA …, 1994 - Elsevier
We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human
melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells
established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome
tautomerase is composed of 519 amino acids with a molecular weight of 59 000 and has
about 84% identity with the mouse counterpart.