Cortical effect of oxaliplatin associated with sustained neuropathic pain: exacerbation of cortical activity and down-regulation of potassium channel expression in …
K Thibault, B Calvino, S Dubacq… - Pain®, 2012 - Elsevier
Oxaliplatin is a third-generation platinum-based chemotherapy drug that has gained
importance in the treatment of advanced metastatic colorectal cancer. Its dose-limiting side
effect is the production of chronic peripheral neuropathy. Using a modified model of
oxaliplatin-induced sensory neuropathy, we investigated plastic changes at the cortical level
as possible mechanisms underlying the chronicity of pain sensation in this model. Changes
in gene expression were studied using DNA microarray which revealed that when …
importance in the treatment of advanced metastatic colorectal cancer. Its dose-limiting side
effect is the production of chronic peripheral neuropathy. Using a modified model of
oxaliplatin-induced sensory neuropathy, we investigated plastic changes at the cortical level
as possible mechanisms underlying the chronicity of pain sensation in this model. Changes
in gene expression were studied using DNA microarray which revealed that when …