Oxaliplatin plays a key role in the treatment of advanced colorectal cancer. The dose-limiting
side effect of this platinum analogue is neurotoxicity. Significant efforts have been
undertaken in an attempt to prevent and/or circumvent the development of neurotoxicity.
Sodium channel inactivation kinetics on rat sensory sural nerve preparations are altered
after exposure to oxaliplatin. Carbamazepine antagonizes this effect in vitro. Results from
preliminary clinical studies indicate that the sodium channel blockers carbamazepine and …