[HTML][HTML] Water immersion stress prevents caerulein-induced pancreatic acinar cell NF-κB activation by attenuating caerulein-induced intracellular Ca2+ changes
AJ Hietaranta, VP Singh, L Bhagat… - Journal of Biological …, 2001 - ASBMB
Prior stress ameliorates caerulein-induced pancreatitis in rats. NF-κB is a proinflammatory
transcription factor activated during caerulein pancreatitis. However, the effects of prior
stress on pancreatic NF-κB activation are unknown. In the current study, the effect of prior
water immersion stress on caerulein and tumor necrosis factor-α (TNF-α)-induced NF-κB
activation in the pancreas was evaluated. Water immersion of rats for up to 6 h prevents
supramaximal caerulein-induced pancreatic IκB-α degradation and NF-κB activation in vivo …
transcription factor activated during caerulein pancreatitis. However, the effects of prior
stress on pancreatic NF-κB activation are unknown. In the current study, the effect of prior
water immersion stress on caerulein and tumor necrosis factor-α (TNF-α)-induced NF-κB
activation in the pancreas was evaluated. Water immersion of rats for up to 6 h prevents
supramaximal caerulein-induced pancreatic IκB-α degradation and NF-κB activation in vivo …